Specific cytotoxicity of arabinosylguanine toward cultured T lymphoblasts.
نویسندگان
چکیده
منابع مشابه
Mechanisms for T-cell selective cytotoxicity of arabinosylguanine.
Nelarabine, prodrug of arabinosylguanine (ara-G), has demonstrated T-lymphoblastic antileukemic activity in cell lines and in the clinic. To investigate the mechanism for lineage-specific toxicity, the effects of ara-G were compared in CEM (T-lymphoblast), Raji (B-lymphoblast), and ML-1 (myeloid) cell lines. CEM cells were the most sensitive to ara-G-induced apoptosis and accumulated the highes...
متن کاملCytotoxicity of Porphyromonas gingivalis toward cultured human gingival fibroblasts.
Direct cytotoxicity of black-pigmented anaerobic rods was studied on the confluent monolayer of human gingival fibroblasts in vitro. Only strains of Porphyromonas gingivalis caused morphological alteration (cell-rounding) and notable depression of viability of fibroblasts. To determine the location of the cytotoxicity, bacterial surface components, i.e., outer membrane, lipopolysaccharide, fimb...
متن کاملSpecific cytotoxicity of a long-term cultured T-cell clone on human autologous mammary cancer cells.
We established an autologous specific T-cell killer clone, TcHMC-1, that has been cultured and has retained its function for over 1 year. TcHMC-1 and target cells (HMC-1-8) were derived from the metastatic pleural effusion of a patient with mammary carcinoma. At culture initiation, pleural exudative lymphocytes (PLEL) already demonstrated a high cytotoxic activity against uncloned HMC-1 breast ...
متن کاملCytotoxicity of human endogenous retrovirus K-specific T cells toward autologous ovarian cancer cells.
PURPOSE To determine whether HERV-K envelope (ENV) protein could function as a tumor-associated antigen and elicit specific T-cell responses against autologous ovarian cancer cells. EXPERIMENTAL DESIGN The expression of HERV-K transcripts and ENV protein, the presence of serum antibodies against HERV-K, reverse transcriptase (RT) activities, and cellular immune responses in primary ovarian ca...
متن کاملInhibition of adenosine deaminase activity results in cytotoxicity to T lymphoblasts in vivo.
We have treated a patient with refractory T-cell acute lymphoblastic leukemia with 2'-deoxycoformycin, a potent inhibitor of the enzyme adenosine deaminase. Inhibition of adenosine deaminase activity resulted in (1) an abrupt rise in plasma deoxyadenosine, but not adenosine, concentrations; (2) accumulation of deoxyadenosine triphosphate by lymphoblasts; (3) inhibition of the enzyme S-adenoylho...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1984
ISSN: 0021-9738
DOI: 10.1172/jci111514